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This family incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, in addition to histone, plenty of non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) advanced, TBP-associated components TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (goal lysine is bold), can be recognized by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the [methyl mark](https://ringworms.space/denniszercho0/legal3118/wiki/How-To-Promote-Your-Dwelling-And-Buy-Another-At-The-Identical-Time) on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a basic model for dynamic lysine methylation of both histone and non-histone proteins.
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